CASE REPORT Simultaneous Detection of IgA/IgG Anti- Tissue Transglutaminase/Deamidated Gliadin Peptides inSerodiagnosis of Celiac Disease
نویسندگان
چکیده
Background: Celiac disease is a common autoimmune disorder that is diagnosed based on clinical case identification, serological screening, and duodenal histology. However, the existence of mild clinical forms, such as seronegative cases with patchy atrophy and potential celiac disease, can make it difficult to determine a definitive diagnosis. The seronegative patients with celiac disease can include those with discordant antibody results and false-negative results, due to unknown origins or selective IgA deficiency. Case presentation: We present two cases with discordant antibody results in order to evaluate if the simultaneous detection of specific antibodies can improve the serodiagnosis of celiac disease. In both patients, the simultaneous detection of IgA/IgG anti-tissue transglutaminase/deamidatedgliadin peptides gave discordant positive results by the same antibodies assayed individually. Conclusion: Although further studies are needed to confirm and extend our findings, the simultaneous detection of specific antibodies seems to improve the serodiagnosis of celiac disease in patients with discordant antibody results. Di TolaM, et al. Iran J Immunol. 2015; 12(1):74-80
منابع مشابه
Simultaneous Detection of IgA/IgG AntiTissue Transglutaminase/Deamidated Gliadin Peptides in Serodiagnosis of Celiac Disease
Background: Celiac disease is a common autoimmune disorder that is diagnosed based on clinical case identification, serological screening, and duodenal histology. However, the existence of mild clinical forms, such as seronegative cases with patchy atrophy and potential celiac disease, can make it difficult to determine a definitive diagnosis. The seronegative patients with celiac disease can i...
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Recently, anti-deamidated gliadin antibodies were proposed for the serological diagnosis of celiac disease. We evaluate the specificity of different anti-deamidated gliadin antibodies ELISA in comparison with conventional anti-native gliadin kits. Serum samples from 46 non celiac patients were analyzed by five different quantitative ELISA for anti-native gliadin, anti-deamidated gliadin and ant...
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متن کاملBINDAZYMETM Human Anti-Gliadin EIA Kit For in-vitro diagnostic use Product code: IgG: MK135 IgA: MK136 IgG or IgA: MK137
Coeliac disease is an inflammatory disease of the small intestine caused by ingestion of wheat gluten or related proteins from rye or barley. In the small intestine, ingested gluten is broken down into gliadin peptides which are deamidated by the enzyme tissue transglutaminase (tTg) resulting in the substitution of glutamine amino acid residues with glutamic acid. These modified gliadin peptide...
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